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  • Title: Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain.
    Author: Chiechio S, Copani A, Melchiorri D, Canudas AM, Storto M, Calvani M, Nicolai R, Nicoletti F.
    Journal: J Endocrinol Invest; 2004; 27(6 Suppl):171-6. PubMed ID: 15481819.
    Abstract:
    Glutamate is the major neurotransmitter in the mammalian central nervous system and plays a pivotal role in both acute and chronic pain. The actions of glutamate are mediated by two receptor families: ionotropic glutamate receptors (iGluRs), and metabotropic glutamate receptors (mGluRs). Activation of glutamate receptor can elicit both hyperalgesic and analgesic effects. Eight mGluRs subtypes (mGluR1-mGluR8) have been identified and classified into three groups. Among these, group I mGluRs (mGlu1 and -5) have been implicated in the processes of central sensitization and persistent nociception, whereas activation of group II mGluRs (mGlu2/3) is effective against neuropathic or inflammatory pain. In this review we focus on the role of mGlu2/3 in the modulation of persistent pain, and on their potential use as drug targets in pain management.
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