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  • Title: Effect of cadmium on changes in concentration of adenine nucleotides induced by mitochondria.
    Author: Ogata M, Hasegawa T, Yamazaki Y, Nogami Y.
    Journal: Acta Med Okayama; 1978 Dec; 32(6):387-92. PubMed ID: 154823.
    Abstract:
    The effect of Cd2+ on the respiration of rat liver mitochondria was investigated. The uncoupling effect of Cd2+ was partially restored by the addition of Mg2+. The influence of Cd2+ on adenine nucleotide concentrations in the reaction mixture consisting of mitochondria and ATP was also studied using high performance liquid chromatography. In the presence of added Mg2+, a two-fold increase in AMP concentration was brought about by the addition of Cd2+. There was a concomitant decrease in ATP. In the prence of added ADP, an increase in AMP concentration was also brought about by addition of Cd2+. The results are discussed in relation to ATPase and adenylate kinase activity in mitochondria.
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