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  • Title: Nimesulide and indomethacin induce apoptosis in head and neck cancer cells.
    Author: Pelzmann M, Thurnher D, Gedlicka C, Martinek H, Knerer B.
    Journal: J Oral Pathol Med; 2004 Nov; 33(10):607-13. PubMed ID: 15482327.
    Abstract:
    BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are known to inhibit the enzyme cyclooxygenase (COX). There are two isoforms of the enzyme. Recent investigations indicate that both isoforms, COX-1 and COX-2, are involved in carcinogenesis. METHODS: We investigated the effects of nimesulide, a COX-2 selective and indomethacin, a non-selective NSAID on the head and neck squamous cell carcinoma (HNSCC) cell lines SCC-9 and SCC-25. Effects on cell numbers and apoptosis were assayed by cell counting, immunofluorescence and fluorescence activated cell sorting (FACS). COX expression was examined by Western blotting. RESULTS: The investigated cell lines express COX-1 and COX-2. Nimesulide and indomethacin induce apoptosis and cause a reduction of cell number. Incubation with NSAIDs upregulated COX-2 expression. CONCLUSION: The results of our study on HNSCC cells together with data from different studies showing anti-cancer activity of NSAIDs suggest that COX inhibitors could play a role in HNSCC treatment and prevention.
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