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  • Title: Aryl urea analogs with broad-spectrum antibacterial activity.
    Author: Seth PP, Ranken R, Robinson DE, Osgood SA, Risen LM, Rodgers EL, Migawa MT, Jefferson EA, Swayze EE.
    Journal: Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5569-72. PubMed ID: 15482926.
    Abstract:
    The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.
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