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  • Title: Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation.
    Author: Doundoulakis T, Xiang AX, Lira R, Agrios KA, Webber SE, Sisson W, Aust RM, Shah AM, Showalter RE, Appleman JR, Simonsen KB.
    Journal: Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5667-72. PubMed ID: 15482944.
    Abstract:
    A series of myxopyronin B analogs has been prepared via a convergent synthetic route and were tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against E. coli and S. aureus. The parent lead compound proved to be very sensitive to even small changes. Only the achiral desmethyl myxopyronin B (1a) provided enhanced potency.
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