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  • Title: Efficacy of rofecoxib for pain control after knee arthroscopy: a prospective, randomized, double-blinded clinical trial.
    Author: Ilan DI, Liporace FA, Rosen J, Cannavo D.
    Journal: Arthroscopy; 2004 Oct; 20(8):813-8. PubMed ID: 15483541.
    Abstract:
    PURPOSE: To determine if rofecoxib 50 mg administered 1 hour preoperatively to patients undergoing arthroscopic knee surgery reduces postoperative pain, provides a narcotic-sparing effect, and reduces time spent in recovery. TYPE OF STUDY: Prospective, randomized, double-blinded clinical trial. METHODS: Fifty patients (age range, 30 to 60 years) undergoing knee arthroscopy under spinal anesthesia were randomized to receive either 50 mg of rofecoxib or placebo 1 hour preoperatively. Postoperatively, pain was assessed in recovery, 8 hours postoperatively, and 24 hours postoperatively, using a 100-mm visual analog scale. Pain medication usage was monitored for 24 hours and time in recovery room was determined. Mann-Whitney tests determined significance between groups. RESULTS: Patients in the rofecoxib group showed significantly lower pain scores at 8 and 24 hours postoperatively. They also showed a significant reduction in postoperative narcotic consumption. CONCLUSIONS: Rofecoxib 50 mg as a single preoperative dose should be considered as part of a perioperative analgesic plan in arthroscopic knee surgery. LEVEL OF EVIDENCE: Level I, Therapeutic Study (randomized controlled trial).
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