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  • Title: Adverse reactions to voriconazole.
    Author: Boyd AE, Modi S, Howard SJ, Moore CB, Keevil BG, Denning DW.
    Journal: Clin Infect Dis; 2004 Oct 15; 39(8):1241-4. PubMed ID: 15486850.
    Abstract:
    Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable--more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.
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