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  • Title: Pathophysiology of parkinsonism due to hydrocephalus.
    Author: Racette BA, Esper GJ, Antenor J, Black KJ, Burkey A, Moerlein SM, Videen TO, Kotagal V, Ojemann JG, Perlmutter JS.
    Journal: J Neurol Neurosurg Psychiatry; 2004 Nov; 75(11):1617-9. PubMed ID: 15489399.
    Abstract:
    We report a patient with hydrocephalus who developed levodopa responsive parkinsonism and severe bradyphrenia associated with shunt malfunction and revision. Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [18F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative sparing of the posterior putamen. Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease.
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