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  • Title: [Intratympanic gentamicin in patients with Ménière's disease: analysis of our protocol].
    Author: Martín Sanz E, Pérez Fernández N.
    Journal: Acta Otorrinolaringol Esp; 2004; 55(6):270-6. PubMed ID: 15491114.
    Abstract:
    OBJECTIVE: The aim of this paper is to analyze the peculiarities of a protocol for treatment with intratympanic gentamicin in patients with Ménière's disease. MATERIAL AND METHODS: 71 patients with unilateral disabling Ménière's disease were followed for a period longer than two years after concluding the treatment. AAO-HNS criteria for reporting treatment results was followed. Gentamicin was applied weekly until of symptoms or signs of vestibular hypofunction were noticed. RESULTS: Control of vertigo was obtained in 83% of the patients while in 24% a second course was needed beacuse of vertigo recurrence. 66% of the patients developed a typical syndrome of unilateral vestibular hypofunction in the ear treated. CONCLUSIONS: Ending weekly injections of gentamicin for the treatment of patients with Ménière's disease when signs of vestibular hypofunction appear warrants a control of vertigo similar to that obtained in other series.
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