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  • Title: Spinal cord compression and lung metastasis of Wilms' tumor in a pregnant adolescent.
    Author: Corapcioglu F, Dillioğlugil O, Sarper N, Akansel G, Calişkan M, Arisoy AE.
    Journal: Urology; 2004 Oct; 64(4):807-10. PubMed ID: 15491732.
    Abstract:
    Wilms' tumor in adults is rare, and no treatment guidelines have been established. Spinal cord compression has also been rarely reported in all age groups. In this case report, we present a 19-year-old adolescent with recurrent Wilms' tumor, a paraspinal dumbbell mass, metastatic involvement of the vertebral bodies, lung metastasis, and pregnancy. To our knowledge, this is the first report of a pregnant patient with Wilms' tumor who had to undergo immediate chemotherapy with vincristine and actinomycin-D owing to spinal cord compression at 25 weeks of pregnancy. After delivery, complete remission was maintained with a regimen of ifosfamide, carboplatin, and etoposide and vincristine, actinomycin-D, and cyclophosphamide. No teratogenic or other toxic effects of vincristine or actinomycin-D were observed in the fetus.
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