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  • Title: Replication vehicles of protein-based inheritance.
    Author: Chernoff YO.
    Journal: Trends Biotechnol; 2004 Nov; 22(11):549-52. PubMed ID: 15491795.
    Abstract:
    Prions are self-perpetuating protein isoforms that are responsible for infectious diseases in mammals and for heritable traits in fungi. Most known prion proteins form amyloids--self-seeded fiber-like aggregates. Prion propagation ('replication') could be described as a sequence of repetitive cycles of aggregate 'shearing' into smaller seeds followed by the growth of these seeds into full-size polymers. Recent work shows that the ability to form aggregates and to propagate them is controlled by distinct regions of the composite prion domains (PrDs).
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