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  • Title: Persistent unilateral tibialis anterior muscle hypertrophy with complex repetitive discharges and myalgia: report of two unique cases and response to botulinum toxin.
    Author: Nix WA, Butler IJ, Roontga S, Gutmann L, Hopf HC.
    Journal: Neurology; 1992 Mar; 42(3 Pt 1):602-6. PubMed ID: 1549222.
    Abstract:
    Unilateral enlargement of the tibialis anterior muscle associated with complex repetitive discharges occurred over several months in two patients and was preceded by pain and numbness in the lower leg. Neuroradiologic investigations excluded a compressive radiculopathy, but pharmacologic and neurophysiologic studies suggested a neurogenic basis for the muscle hypertrophy. Botulinum toxin A injection into the hypertrophied muscles led to a decreased muscle volume and cessation of muscle pain.
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