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  • Title: Copper(II)-quenched oligonucleotide probes for fluorescent DNA sensing.
    Author: Brunner J, Kraemer R.
    Journal: J Am Chem Soc; 2004 Oct 27; 126(42):13626-7. PubMed ID: 15493914.
    Abstract:
    A copper(II)-quenched molecular beacon was prepared by attaching fluorescein to the 3'-end and a copper(II) complex to the 5'-end of DNA. In the presence of complementary DNA, copper(II) and dye are spatially separated in the duplex and fluorescence increases up to 15-fold, with excellent discrimination of single base mismatches.
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