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  • Title: Positive predictive value of Gen-Probe APTIMA Combo 2 testing for Neisseria gonorrhoeae in a population of women with low prevalence of N. gonorrhoeae infection.
    Author: Golden MR, Hughes JP, Cles LE, Crouse K, Gudgel K, Hu J, Swenson PD, Stamm WE, Handsfield HH.
    Journal: Clin Infect Dis; 2004 Nov 01; 39(9):1387-90. PubMed ID: 15494917.
    Abstract:
    We collected specimens from women who tested positive for Neisseria gonorrhoeae using the Gen-Probe APTIMA Combo 2 (AC2), and we performed confirmatory tests using a nucleic acid amplification test (NAAT) that targets alternate gonococcal nucleic acid sequences. Among 59,664 specimens, 280 (0.47%) had positive results using AC2; 265 of these specimens were tested using the confirmatory NAAT, of which 258 yielded positive results (positive predictive value, 97.4%; 95% confidence interval, 95.1%-98.8%). Routine confirmatory testing of specimens with positive AC2 gonorrhea test results is not indicated.
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