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  • Title: Low-temperature deacylation of N-monosubstituted amides.
    Author: Spaggiari A, Blaszczak LC, Prati F.
    Journal: Org Lett; 2004 Oct 28; 6(22):3885-8. PubMed ID: 15496055.
    Abstract:
    [reaction: see text] The (PhO)(3)P.Cl(2) reagent, prepared in situ by titrating a solution of triphenyl phosphite with chlorine, is used to convert N-monosubstituted amides into their corresponding amines. The reaction, if compared to other traditional methods, shows the advantage of very mild conditions and low temperature (-30 degrees C-->rt).
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