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  • Title: Enantioselective Cu-catalyzed conjugate addition of diethylzinc to acyclic aliphatic enones.
    Author: Duncan AP, Leighton JL.
    Journal: Org Lett; 2004 Oct 28; 6(22):4117-9. PubMed ID: 15496113.
    Abstract:
    [reaction: see text] A new P-chiral phosphine bis(sulfonamide) ligand has been developed that allows the Cu-catalyzed enantioselective conjugate addition of Et(2)Zn to acyclic aliphatic enones. The reactions proceed with excellent levels of enantioselectivity (90-95% ee) with a range of enone substrates, involve the use of only 1.2 equiv of Et(2)Zn, and give best results at ambient temperature.
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