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  • Title: A novel preparation of solid lipid nanoparticles with cyclosporin A for prolonged drug release.
    Author: Hu FQ, Wu MZh, Yuan H, Zhang HH.
    Journal: Pharmazie; 2004 Sep; 59(9):683-5. PubMed ID: 15497749.
    Abstract:
    Solid lipid nanoparticles were prepared by a novel solvent diffusion method in an aqueous system. The lipophilic model drug cyclosporin A was incorporated into SLN to study encapsulation efficiency, zeta potential (charge) and drug delivery. Stearylamine and cyclosporin A were dissolved in ethanol and acetone and the resultant organic solution was dropped into water at 60 degrees C. The drug-loaded SLN suspension quickly formed with an azury color. After burst drug release with 18% of the drug over the first 12 hours, a distinctly prolonged release over a monitored period of 16 days was observed, with nearly 4% of the drug being released each day. These results demonstrate the suitability of SLN produced with the proposed method as a prolonged release formulation for lipophilic drugs.
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