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  • Title: Synthesis and antihyperglycemic activity profiles of novel thiazolidinedione derivatives.
    Author: Bhat BA, Ponnala S, Sahu DP, Tiwari P, Tripathi BK, Srivastava AK.
    Journal: Bioorg Med Chem; 2004 Nov 15; 12(22):5857-64. PubMed ID: 15498661.
    Abstract:
    A number of thiazolidine-2,4-diones derivatives having carboxylic ester appendage at N-3 were synthesized and their antihyperglycemic activity was evaluated. Many of these derivatives as well as their corresponding carboxylic acid showed significant improvement on post-prandial hyperglycemia in normal rats, in contrast to their poor agonist activity at PPARgamma.
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