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  • Title: Synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring.
    Author: Jo YW, Im WB, Rhee JK, Shim MJ, Kim WB, Choi EC.
    Journal: Bioorg Med Chem; 2004 Nov 15; 12(22):5909-15. PubMed ID: 15498667.
    Abstract:
    A series of oxazolidinone derivatives, which morpholino group of linezolid was replaced with heteroaromatic ring substituted pyridine moiety, were newly synthesized, and their substituted effects on in vitro and in vivo antibacterial activities were evaluated against four problematic gram-positive strains including drug resistant strains and two gram-negative strains. Most compounds exhibited the enhanced in vitro activities with 4-16-fold and three compounds exerted more than 2-fold increased in vivo efficacies than linezolid.
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