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  • Title: Relation of short-term pyridoxine-HCl supplementation to plasma vitamin B-6 vitamers and amino acid concentrations in young women.
    Author: Kang-Yoon SA, Kirksey A.
    Journal: Am J Clin Nutr; 1992 Apr; 55(4):865-72. PubMed ID: 1550070.
    Abstract:
    Pyridoxal 5'-phosphate (PLP) is a coenzyme in many metabolic transformations of amino acids and may play a role in their absorption and transport. This investigation analyzed the effects of large oral doses (27 mg/d) of pyridoxine (PN)-HCl over 2 wk on plasma PLP and amino acid concentrations in 10 young women. Plasma PLP was 45 +/- 2 nmol/L (means +/- SE) initially and reached 377 +/- 12 nmol/L after 7 d of supplementation. A steady-state PLP concentration remained as long as daily PN-HCl supplementation was continued. Plasma glutamic acid concentration was significantly lower after 7 and 14 d of supplementation whereas alpha-amino-N-butyric acid, alanine, cysteine, arginine, phosphoserine, and urea concentrations were significantly higher, particularly alpha-amino-N-butyric acid and cysteine. Altered plasma amino acid profiles and increased plasma urea concentrations in response to supplementation suggested accelerated protein and/or amino acid metabolism.
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