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  • Title: Unprecedented olefin-dependent histidine-kinase inhibitory of zerumbone ring-opening material.
    Author: Kitayama T, Iwabuchi R, Minagawa S, Shiomi F, Cappiello J, Sawada S, Utsumi R, Okamoto T.
    Journal: Bioorg Med Chem Lett; 2004 Dec 06; 14(23):5943-6. PubMed ID: 15501073.
    Abstract:
    Zerumbone ring-opening derivative, 4 (10E/10Z=3/2), inhibited autophosphorylation of the essential histidine-kinase YycG existing in Bacillus subtilis constituting a two-component system (TCS). Generation of 4E-form could be regulated chemically using the difference from the ring-opening reactivity of the precursor forming of 4 and pure 4E was isolated. The stereoisomer, 4E, showed main inhibition activity of autophosphorylation of YycG (IC(50)=63.5 microM).
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