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  • Title: Serum lead, cadmium, and zinc levels in newborns with neural tube defects from a polluted zone in Mexico.
    Author: Carrillo-Ponce Mde L, Martínez-Ordaz VA, Velasco-Rodríguez VM, Hernández-García A, Hernández-Serrano MC, Sanmiguel F.
    Journal: Reprod Toxicol; 2004 Dec; 19(2):149-54. PubMed ID: 15501379.
    Abstract:
    Serum lead, cadmium and zinc levels from 31 newborns with neural tube defects (NTD), and 54 healthy controls living in a polluted area in Mexico were estimated using atomic absorption spectrophotometry (AAS). NTD family history was found to be of greater importance in the case group (OR 6.95, 95% CI 1.51-36.3, p=0.002). In 25% of the children, serum lead concentrations were above the admissible maximum level (AML) of 10 microg/dL within 24 h of extra-uterine life. Cadmium concentrations were below the AML. Zinc deficiency was found in nine (29%) of the cases and four (9.3%) of the controls (p=0.04). The logistic regression multivariate analysis showed no correlation between NTD and high levels of any of these metals; however, a positive correlation was found to zinc deficiency (OR 5.0, 95% CI 1.07-23.00, p=0.04). These results focus attention to the surrounding nutritional and maternal health factors of major importance in disease etiology.
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