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  • Title: Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.
    Author: Motoyoshi H, Horigome M, Ishigami K, Yoshida T, Horinouchi S, Yoshida M, Watanabe H, Kitahara T.
    Journal: Biosci Biotechnol Biochem; 2004 Oct; 68(10):2178-82. PubMed ID: 15502365.
    Abstract:
    The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.
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