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  • Title: Mechanical and structural properties of a novel hybrid heart valve scaffold for tissue engineering.
    Author: Grabow N, Schmohl K, Khosravi A, Philipp M, Scharfschwerdt M, Graf B, Stamm C, Haubold A, Schmitz KP, Steinhoff G.
    Journal: Artif Organs; 2004 Nov; 28(11):971-9. PubMed ID: 15504112.
    Abstract:
    Hybrid heart valve scaffolds were fabricated from decellularized porcine aortic heart valve matrices and enhanced with bioresorbable polymers using different protocols: (i) dip coating of lyophilized decellularized matrices, and (ii) impregnation of wet decellularized matrices. The following polymers were evaluated: poly(4-hydroxybutyrate) and poly(3-hydroxybutyrate-co4-hydroxybutyrate). Tensile tests were conducted to assess the biomechanical behavior of valve leaflet strips. Suture retention strength was evaluated for the adjacent conduit. A pulse duplicator system was used for functional testing of the valves under physiological systemic load conditions. The properties of the hybrid structures were compared with native, decellularized, and glutaraldehyde-fixed specimens. Mechanisms of the polymer impregnation process were studied with IR spectroscopy, fluorescent microscopic imaging, and SEM. Altogether this study demonstrates the feasibility and improved biomechanical function of a novel hybrid heart valve scaffold for an application in tissue engineering.
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