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  • Title: Pamidronate treatment in acute vitamin D intoxication.
    Author: Gurkan F, Davutoglu M, Bosnak M, Ece A, Dikici B, Bilici M, Haspolat K.
    Journal: J Endocrinol Invest; 2004; 27(7):680-2. PubMed ID: 15505994.
    Abstract:
    Management with glucocorticoid, high iv fluid saline intake, furosemide and calcitonin may not result in a favorable reduction of hypercalcemia and may cause several side effects in infants with acute vitamin D intoxication. The bisphosphonate pamidronate, a specific inhibitor of bone resorption through osteoclast mediation was successfully used in a 6-month old infant with acute vitamin D intoxication managed in the Pediatric Emergency and Intensive Care Unit, after an ineffective trial of hydration, furosemide, calcitonin and prednisolone. After a double infusion of pamidronate on two consecutive days (1 mg/kg/day), an early and safe correction of hypercalcemia/hypercalciuria was supplied. Pamidronate therapy may be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.
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