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  • Title: Effects of Tyr-MIF's family of peptides on immobilization stress-induced antinociception in rats.
    Author: Bocheva AI, Dzambazova-Maximova EB.
    Journal: Folia Med (Plovdiv); 2004; 46(2):42-6. PubMed ID: 15506550.
    Abstract:
    UNLABELLED: The Tyr-MIF-1 family of peptides includes MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1, which have been isolated from bovine hypothalamus and cortex of human brain. Data in the literature suggest that peptides of Tyr-MIF-1's family have opioid-like and anti-opioid actions. All these peptides interact with opioid receptors and in addition bind to non-opiate sites specific for each of the peptides and able to inhibit the expression of some forms of stress-induced analgesia (SIA) in various species. AIM: To examined the effects of the Tyr-MIF-1's peptides on immobilization stress-induced antinociception. METHODS: Tyr-MIF-1's peptides were given to male Wistar rats intraperitoneally before or after 1 hour of restraint. The changes in the mechanical nociceptive threshold of the animals were measured by the Randall-Selitto paw pressure test. RESULTS: Immobilization of the rats increased the pain threshold at least 1 h. Tyr-MIF-1's peptides have contrasting effects on immobilization stress-induced antinociception in paw-pressure test in rats. When administered before immobilization procedure they potentiated the immobilization stress-induced antinociception, while if given after immobilization, they reduced it. Antinociceptive effects of Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1 were reduced in condition of stress. CONCLUSION: Tyr-MIF-1's peptides exerted antiopioide effects under condition of stress in paw-pressure test. These antiopioide effects were more pronounced when peptides were injected after stress exposure.
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