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  • Title: Effects of Papaver rhoeas extract on the expression and development of morphine-dependence in mice.
    Author: Pourmotabbed A, Rostamian B, Manouchehri G, Pirzadeh-Jahromi G, Sahraei H, Ghoshooni H, Zardooz H, Kamalnegad M.
    Journal: J Ethnopharmacol; 2004 Dec; 95(2-3):431-5. PubMed ID: 15507371.
    Abstract:
    The problem of drug dependence still remains unresolved. In the present study, the effects of water-alcohol extract of Papaver rhoeas on the expression and acquisition of naloxone-induced jumping and diarrhea in morphine-dependent mice were investigated. Administration of three daily doses of morphine (12.5, 25 and 50 mg/kg) for three days in order to develop dependence to morphine caused a significant and dose-dependent increase in the number of jumping and diarrhea when the animals were challenged with naloxone (4 mg/kg). On the other hand, administration with the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg) 30 min before the naloxone administration in morphine-dependent mice decreased the number of jumping and diarrhea. Administration of extract (25, 50 and 100 mg/kg) 30 min before morphine injection increased the number of jumping but decreased the diarrhea. It could be concluded that the extract of Papaver rhoeas can ameliorate the withdrawal syndrome in morphine-dependent mice. Therefore, the extract might be useful to treatment of withdrawal signs in opioid addicts.
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