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  • Title: Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U.
    Author: Yokota M, Ozaki Y, Sakamoto F, Yamada S, Saito J, Fujihara H, Ueta Y.
    Journal: Stress; 2004 Jun; 7(2):109-12. PubMed ID: 15512854.
    Abstract:
    We examined the effects of centrally administered neuromedin U (NMU) on corticotrophin-releasing factor (CRF)-containing neurons in the hypothalamic paraventricular nucleus (PVN) of rats, using double immunohistochemistry for CRF and Fos. Almost all CRF-containing neurons in the parvocellular divisions of the PVN expressed Fos-like immunoreactivity 90 min after intracerebroventricular administration of NMU (3 nmol/rat). This results suggest the possibility that central NMU may be involved in stress-induced activation of CRF-containing neurons in the PVN.
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