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  • Title: A pilot study of D-cycloserine in subjects with autistic disorder.
    Author: Posey DJ, Kem DL, Swiezy NB, Sweeten TL, Wiegand RE, McDougle CJ.
    Journal: Am J Psychiatry; 2004 Nov; 161(11):2115-7. PubMed ID: 15514414.
    Abstract:
    OBJECTIVE: The authors assessed the effects of D-cycloserine on the core symptom of social impairment in subjects with autism. METHOD: Following a 2-week, single-blind placebo lead-in phase, drug-free subjects with autistic disorder were administered three different doses of D-cycloserine during each of three 2-week periods. Measures used for subject ratings included the Clinical Global Impression (CGI) scale and Aberrant Behavior Checklist. RESULTS: Significant improvement was found on the CGI and social withdrawal subscale of the Aberrant Behavior Checklist. d-Cycloserine was well tolerated at most of the doses used in this study. CONCLUSIONS: In this pilot study, D-cycloserine treatment resulted in significant improvement in social withdrawal. Further controlled studies of D-cycloserine in autism appear warranted.
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