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  • Title: Changes in hemodynamics and respiration in rats with different resistance to acute hypoxia.
    Author: Sanotskaya NV, Matsievskii DD, Lebedeva MA.
    Journal: Bull Exp Biol Med; 2004 Jul; 138(1):18-22. PubMed ID: 15514712.
    Abstract:
    Effects of acute hypoxia on hemodynamics and respiration were studied in acute experiments on narcotized rats. The animals were divided into groups characterized by high, low-, and medium- resistance to hypoxia by the time of respiration arrest during inhalation of gas mixture containing 3% O2. Hemodynamic parameters of highly resistant animals were higher than in low-resistant rats throughout the entire hypoxic period. The development of a rare (with prolonged inspiratory phase) respiratory rhythm in highly resistant rats is an adaptive reaction, which allows them longer tolerate hypoxia compared to low-resistant animals.
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