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  • Title: Antigenic differences between apo-B in native and circulating modified low-density lipoproteins.
    Author: Suprun IV, Mel'nichenko AA, Yanushevskaya EV, Vlasik TN, Sobenin IA, Panasenko OM, Orekhov AN.
    Journal: Bull Exp Biol Med; 2004 Jul; 138(1):42-4. PubMed ID: 15514719.
    Abstract:
    The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.
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