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  • Title: Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis.
    Author: Luzhetskyy A, Liu T, Fedoryshyn M, Ostash B, Fedorenko V, Rohr J, Bechthold A.
    Journal: Chembiochem; 2004 Nov 05; 5(11):1567-70. PubMed ID: 15515090.
    Abstract:
    The glycosyltransferase gene lanGT3, involved in the biosynthesis of the angucyclic antibiotic landomycin A, has been characterised by targeted gene deletion. A lanGT3 mutant was shown to produce landomycin E, which consists of a trisaccharide side chain attached to the polyketide moiety. Expression of lanGT3 in the mutant restored landomycin A production. Our results indicate that LanGT3 is responsible for the transfer of the fourth sugar during landomycin A biosynthesis.
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