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  • Title: Detection of fetal lactate with two-dimensional-localized proton magnetic resonance spectroscopy.
    Author: Robinson JN, Cleary-Goldman J, Arias-Mendoza F, Cruz-Lobo J, Tempany C, Mulkern RV, Feinberg BB, Brown TR.
    Journal: Obstet Gynecol; 2004 Nov; 104(5 Pt 2):1208-10. PubMed ID: 15516455.
    Abstract:
    BACKGROUND: Antenatal surveillance is inefficient for accurately detecting fetal compromise. A noninvasive technique for assessing fetal metabolic status would be useful for clinical management. CASE: Fetal magnetic resonance spectroscopy was performed at 20 weeks in a pregnancy complicated by severe intrauterine growth restriction to determine if lactate, a metabolite associated with fetal hypoxia, was present. Two-dimensional, single-slice proton magnetic resonance spectroscopy was carried out at 1.5 T using a volume-selective, double-spin echo technique. Lactate was detected in fetal back muscle. Fetal death occurred the next day. CONCLUSIONS: Although this initial report is purely experimental, further development of this technique may prove to be a valuable noninvasive tool in the management of suspected fetal hypoxia.
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