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  • Title: [The role of platelet-derived growth factor A (PDGF-A) in hypertension and renal diseases. Part 2: a role of PDGF-A in kidney diseases].
    Author: Miller-Kasprzak E, Niemir ZI, Czekalski S.
    Journal: Pol Merkur Lekarski; 2004 Apr; 16(94):403-5. PubMed ID: 15517944.
    Abstract:
    Many studies have suggested deleterious effects of platelet-derived growth factor (PDGF) released by intrinsic renal cells during glomerulonephritis (GN). Increase in PDGF B chain expression has particularly been noted in glomeruli of patients with GN. Less known is the role of PDGF A chain both in the normal kidney and renal diseases. Several lines of evidence have indicated the involvement of PDGF-A in renal graft rejection. Furthermore, an increased expression of PDGF-A has also been observed in the course of human diabetic nephropathy. Still, the role of PDGF-A in the development and progression of GN remains unclear.
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