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  • Title: Placental protein 14 in human in-vitro fertilization early pregnancies.
    Author: Nylund L, Gustafson O, Lindblom B, Pousette A, Seppälä M, Riittinen L, Akerlöf E.
    Journal: Hum Reprod; 1992 Jan; 7(1):128-30. PubMed ID: 1551949.
    Abstract:
    Placental protein 14 (PP14) and human chorionic gonadotrophin (HCG) were analysed in patients participating in an in-vitro fertilization-embryo transfer programme which did not include any kind of luteal support. Women with normal pregnancies, spontaneous abortions, ectopic pregnancies, biochemical pregnancies and non-pregnant women were compared. A combination of HCG and PP14 analyses distinguished between normal and abnormal implantation as early as 15 days after oocyte retrieval. The product of HCG (IU/l) and PP14 (micrograms/l) concentrations differed significantly between normal pregnancy, spontaneous abortion and ectopic pregnancy (P = 0.0248). It is concluded that both endometrial (PP14) and trophoblastic (HCG) markers, when used in combination, exhibit changes in abnormal implantation which may be clinically useful.
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