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  • Title: No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population.
    Author: Yu YQ, Tao R, Wei J, Xu Q, Liu SZ, Ju GZ, Shi JP, Zhang X, Xie L, Shen Y.
    Journal: Prostaglandins Leukot Essent Fatty Acids; 2004 Dec; 71(6):405-8. PubMed ID: 15519500.
    Abstract:
    The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.
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