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  • Title: Variability of markers of inflammation and infection in induced sputum in children with cystic fibrosis.
    Author: Ordoñez CL, Kartashov AI, Wohl ME.
    Journal: J Pediatr; 2004 Nov; 145(5):689-92. PubMed ID: 15520781.
    Abstract:
    To determine reproducibility of inflammatory marker concentrations in induced sputum from subjects with cystic fibrosis (CF), 15 nonexpectorating children, 6 to 13 years of age with mild CF lung disease, underwent 3 weekly sputum inductions with 3% saline. Neutrophil elastase concentration and bacterial cultures were reproducible. This study provides useful information for investigators designing trials of anti-inflammatory therapies in CF involving sputum induction.
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