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  • Title: SRP meets the ribosome.
    Author: Wild K, Halic M, Sinning I, Beckmann R.
    Journal: Nat Struct Mol Biol; 2004 Nov; 11(11):1049-53. PubMed ID: 15523481.
    Abstract:
    Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.
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