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  • Title: Synthesis and lectin binding ability of glycosamino acid-calixarenes exposing GlcNAc clusters.
    Author: Consoli GM, Cunsolo F, Geraci C, Sgarlata V.
    Journal: Org Lett; 2004 Nov 11; 6(23):4163-6. PubMed ID: 15524433.
    Abstract:
    Novel calix[4 or 8]arene-based glycoconjugates exposing terminal N-acetyl-D-glucosamine clusters have been synthesized using amino acid-calixarenes as building blocks. The obtained glycosamino acid-calixarenes 9b-14b have lectin-binding ability and amplified inhibitory effects on erythrocyte agglutination induced by wheat germ (Triticum vulgaris) agglutinin (WGA). The inhibitory ability is dependent on the presence of the spacer and on the shape and rigidity of the calixarene skeleton.
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