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  • Title: Spatially resolved electronic detection of biopolymers.
    Author: Pouthas F, Gentil C, Côte D, Zeck G, Straub B, Bockelmann U.
    Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2004 Sep; 70(3 Pt 1):031906. PubMed ID: 15524548.
    Abstract:
    An integrated array of field-effect transistor structures is used to detect two oppositely charged biopolymers: poly(L-lysine) and DNA. Local deposition of polymer solutions on part of the array induces sizeable variations in the dc current-voltage characteristics of the transistors exposed to the molecular charge. The whole transistor array is measured in the presence of a common electrolyte. Differential signals are studied as a function of electrolyte salt and polymer concentrations. The measurements provide information on the interface electrostatic potentials of the (semiconductor/biopolymer/electrolyte) system and the experimental data are compared to an analytical model which accounts for screening of the adsorbed charge by mobile ions.
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