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  • Title: 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.
    Author: Seckl JR.
    Journal: Curr Opin Pharmacol; 2004 Dec; 4(6):597-602. PubMed ID: 15525550.
    Abstract:
    11beta-hydroxysteroid dehydrogenases (11beta-HSDs) catalyse the interconversion of active cortisol and inert cortisone. Two isozymes have been discovered, each with unique properties and powerful biological roles. 11beta-HSD2 potently inactivates cortisol, protecting key tissues. By contrast, 11beta-HSD1 regenerates cortisol, amplifying its actions in liver, fat and brain. Overexpression of this isozyme may contribute to the pathogenesis of the metabolic syndrome. Its inhibition is a potential therapeutic target for both metabolic and glucocorticoid-associated CNS disorders.
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