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  • Title: Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome.
    Author: Gandhi S, Little MA, Farrington K.
    Journal: Ren Fail; 2004 Sep; 26(5):591-6. PubMed ID: 15526921.
    Abstract:
    We report a case of Waldenstrom's macroglobulinemia (WM) presenting as classic Goodpasture's syndrome. Thrombocytopenia, an additional autoimmune phenomenon, further complicated the clinical course. Renal disease is well recognized in Waldenstrom's macroglobulinemia and other B-cell dyscrasias. Similarly, a wide spectrum of autoimmune-mediated conditions has been reported in association with paraproteinemia. However, rapidly progressive glomerulonephritis in association with antiglomerular basement membrane antibodies has never been reported as either an autoimmune or a renal manifestation of WM. This article reviews the current understanding of renal pathology and autoimmune phenomenon associated with WM.
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