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  • Title: Asymmetric synthesis of 3-substituted proline chimeras bearing polar side chains of proteinogenic amino acids.
    Author: Quancard J, Labonne A, Jacquot Y, Chassaing G, Lavielle S, Karoyan P.
    Journal: J Org Chem; 2004 Nov 12; 69(23):7940-8. PubMed ID: 15527274.
    Abstract:
    The amino-zinc-ene-enolate cyclization reaction is a straightforward route to the synthesis of 3-substituted prolines. Herein we report the application of this reaction to the syntheses of proline chimeras of lysine, glutamic acid, glutamine, arginine, and serine. All these compounds were obtained in enantiomerically pure form and suitably protected for peptide synthesis.
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