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  • Title: Unique amino acid polymorphisms of PrP genes in Mongolian sheep breeds.
    Author: Gombojav A, Ishiguro N, Horiuchi M, Shinagawa M.
    Journal: J Vet Med Sci; 2004 Oct; 66(10):1293-5. PubMed ID: 15528869.
    Abstract:
    To characterize amino acid polymorphisms of sheep prion protein (PrP) gene, DNA from 740 sheep of nine breeds raised in Mongolia was isolated and analyzed. A total of 16 genotypes and seven allelic variants of the PrP gene at codons 112, 136, 154, and 171 were found. The MARQ/MARQ genotype associated with susceptibility to scrapie was found in 82.6% of the sheep while the MARR/MARR genotype associated with resistance to scrapie was found in 1.8% of the sheep. The polymorphisms of valine and serine at codon 127, and leucine and arginine at codon 189 were detected in eight Mongolian sheep breeds, suggesting that these polymorphisms are a common feature among Mongolian sheep breeds.
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