These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat.
    Author: Leegsma-Vogt G, van der Werf S, Venema K, Korf J.
    Journal: J Cereb Blood Flow Metab; 2004 Oct; 24(10):1071-80. PubMed ID: 15529007.
    Abstract:
    Venous-arterial lactate differences across the brain during lactate infusion in rats were studied, and the fate of lactate was described with a mathematical model that includes both cerebral and extracerebral kinetics. Ultrafiltration was used to sample continuously and simultaneously arterial and venous blood. Subsequent application of flow injection analysis and biosensors allowed the measurement of glucose and lactate concentrations every minute. Because of the high temporal resolution, arteriovenous lactate kinetics could be modeled in individual experiments. The existence of both a cerebral lactate sink and a lactate exchangeable compartment, representing approximately 24% of brain volume, was thus modeled.
    [Abstract] [Full Text] [Related] [New Search]