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  • Title: Photoinitiated DNA Binding by cis-[Ru(bpy)2(NH3)2]2+.
    Author: Singh TN, Turro C.
    Journal: Inorg Chem; 2004 Nov 15; 43(23):7260-2. PubMed ID: 15530069.
    Abstract:
    The ligand-loss photochemistry of cis-[Ru(bpy)(2)(NH(3))(2)](2+) (bpy = 2,2'-bipyridine) was investigated in water and in the presence of added ligands such as bipyridine and chloride. Irradiation of the complex results in the covalent binding to 9-methyl- and 9-ethylguanine, as well as to single-stranded and double-stranded DNA. This photoinduced DNA binding is not observed for the control complex [Ru(bpy)(2)(en)](2+) (en = ethylenediamine) under similar irradiation conditions. The results presented here show that octahedral Ru(II) complexes with photolabile ligands may prove useful as photoactivated cisplatin analogs.
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