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  • Title: A base-catalyzed solution-phase parallel synthesis of substituted vinylic benzamides from 3-amino-2-cyclohexanones.
    Author: Anderson AJ, Nicholson JM, Bakare O, Butcher RJ, Scott KR.
    Journal: J Comb Chem; 2004; 6(6):950-4. PubMed ID: 15530123.
    Abstract:
    An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented. Using sodium hydride, a base-catalyzed N-benzoylation provided significantly higher yields (71-79%) for the reported compounds. This novel protocol was applied in the solution-phase parallel synthesis of a 12-member library of vinylic benzamide derivatives of 3-amino-2-cyclohexenones in 63-90% yield, using a Radley's Carousel Reaction Station.
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