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  • Title: Antibody responses to intradermal recombinant hepatitis B immunization among HIV-positive subjects.
    Author: Ristola MA, Vuola JM, Valle M, von Reyn CF.
    Journal: Vaccine; 2004 Nov 25; 23(2):205-9. PubMed ID: 15531038.
    Abstract:
    We conducted a randomized, controlled clinical trial to determine the immunogenicity of intradermal immunization with recombinant hepatitis B vaccine among HIV-positive subjects. Induction of antibody concentration over 10 IU/L or four-fold increase in the antibody concentration against hepatitis B surface antigen was regarded a successful immunization. Intradermal immunization induced protective immunity in 39% of participants who received three doses of recombinant hepatitis B vaccine. Intradermal immunization may provide a way to improve the outcome of hepatitis B vaccination among HIV-infected persons. Three doses of intradermal immunization alone induces protective immunity against hepatitis B as often as intramuscular immunization.
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