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  • Title: A pilot study on the efficacy of ketorolac plus tramadol infusion combined with erythrocytapheresis in the management of acute severe vaso-occlusive crises and sickle cell pain.
    Author: de Franceschi L, Finco G, Vassanelli A, Zaia B, Ischia S, Corrocher R.
    Journal: Haematologica; 2004 Nov; 89(11):1389-91. PubMed ID: 15531461.
    Abstract:
    One of the major causes of hospitalization for patients with sickle cell disease (SCD) are vaso-occlusive crises (VOC), which are characterized by acute pain and organ damage related to the presence of dense red cells. Here we report a pilot study which combined balanced analgesia with tramadol plus ketorolac and erythrocytapheresis. Key words: sickle cell disease, therapeutic erythrocytapheresis, HbS, visual analog scale, vaso-occlusive crisis.
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