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  • Title: [Antimicrobial activity of blood phagocytes in patients with tuberculosis and respiratory sarcoidosis].
    Author: Makinskiĭ AI, Borisov SE, Petrova LIu.
    Journal: Probl Tuberk Bolezn Legk; 2004; (9):42-5. PubMed ID: 15532468.
    Abstract:
    Examination of 82 patients has revealed that pulmonary tuberculosis is characterized by a considerable increase in the antimicrobial activity of phagocytes: the drastic elevation of the plasma level of neutrophilic elastase and the changes opposite in direction in the phagocytic content of nonenzymatic cation proteins and myeloperoxidase. There is evidence for that the activation of circulating phagocytes is much less pronounced in patients with respiratory sarcoidosis. The significantly less plasma activity of neutrophilic elastase and the significantly greater phagocytic values of cation proteins suggest that the synthesis of secretion products prevails over their degranulation in sarcoidosis. It has been shown that the simultaneous determination of nonenzymatic cation proteins and myeloperoxidase in the phagocytes of patients allows the diagnosis to be established in 33.3% of cases.
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